Hypothetical Link between some widely used Blood Pressure Medications and Increased Sensitivity to COVID-19 Infection.

The topic of this article is still a hypothesis, and I am updating it as important news comes in.  However it will take some time to confirm or refute it.  People on these medications should take prudent social distancing measures in the interim.  There is no current consensus to change your medications however, and stopping blood pressure medication can be dangerous.  Some medical authorities are already disputing this hypothesis as noted below, but others call for more research.


 

Last significant update of the main text on Monday, 3/16 at 11:55 AM Pacific Daylight Time.  Please see the Comments section following the main article for additional ongoing details.

A possibly very important article appeared in the Lancet medical journal recently:

https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext

In brief, the article states that people treated with specific classes of blood pressure medications (meds that are also used on some people with diabetes) have increased amounts of the ACE2 protein that the novel coronavirus binds to when it attacks lung cells.

The article states “We therefore hypothesise that diabetes and hypertension treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19.

Note, of course, the word “hypothesise” (sic – hypothesize, unless this is UK spelling – the corresponding author is from Switzerland).  This hypothesis is not proven, but seems very plausible.

This hypothesis is similar to a question that I raised on local social media a few days ago in regards to ACE inhibitors (ACEI), especially lisinopril which causes “lisinopril cough,” at

https://nextdoor.com/post/139950824

[Sorry, but the link above will only work for people in my nearby neighborhood location (San Mateo, CA) with Nextdoor accounts.]

A local doctor, Dr. Raymond Hong who is an allergist, saw this post and commented that he believed that only Angiotensin Receptor Blocker (ARB) drugs increased the number of ACE2 receptor proteins that the novel coronavirus attacks, not ACE inhibitors.  He also thought that this was a very interesting hypothesis that needed additional research.

He cautioned (I added bolding in his quote for emphasis):

“Although this sounds concerning, in no way am I advocating stopping or switching angiotensin receptor blockers (or ace inhibitors) or discussing this with your doctor quite yet. But I agree we should definitely be looking at the patients with severe COVID-19 disease to see what medical conditions they have, and if they have hypertension, what medications they are on. Any positive findings might help spur more caution and studies. There may be multiple factors involved and I just thought I’d respond to your question in a responsible manner.”

Personally, I (Kristofferson) should note that changing medications will NOT cause the levels of these lung proteins that the virus attacks to decrease overnight.  If this hypothesis turns out to be correct (and unfortunately its resolution may take too long to help people currently at risk for COVID-19), my take is that people on these medications should take extra precautions to avoid exposing themselves to sick individuals.  This undoubtedly means hunkering down at home given the latest developments.

This hypothesis could also explain why young people might develop severe coronavirus cases – they might be at risk if they have elevated ACE2 levels as a result of using ACEI/ARB medications.

A new JAMANetwork review article (link added near the end of this article) states that it is possible that either genetics or the high rate of smoking among Chinese men may have increased their ACE2 levels and made them more susceptible to the disease, but, again, this is not yet proven:  “The ACE2 enzyme is expressed in type II alveolar cells, and some unconfirmed data suggest that Asian males have a large number of ACE2-expressing cells in the lung, which may partially explain the male predominance of COVID-19. However, other factors such as a higher prevalence of smoking among men in China may explain the difference in the sex distribution of the disease.”

Dr. Hong has just (3/13/2020 5:45 PM PDT) notified me of the following news:

I think it’s too early to make recommendations about switching. In fact because of social media posts similar to mine, there has been concern about patients stopping their blood pressure medications. The European Society of Cardiology published a position statement to not stop ace inhibitors or arbs as there is no evidence to support this. They stated there is evidence in animals that these medications might even be protective against serious lung complications from COVID-19. So they recommended against making any changes.

Here is the official statement that he notes above:

Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers

This ESC article clearly contradicts The Lancet article and states:

This speculation about the safety of ACE-i or ARB treatment in relation to COVID-19 does not have a sound scientific basis or evidence to support it. Indeed, there is evidence from studies in animals suggesting that these medications might be rather protective against serious lung complications in patients with COVID-19 infection, but to date there is no data in humans.

The Council on Hypertension of the European Society of Cardiology wish to highlight the lack of any evidence supporting harmful effect of ACE-I and ARB in the context of the pandemic COVID-19 outbreak.

The Council on Hypertension strongly recommend that physicians and patients should continue treatment with their usual anti-hypertensive therapy because there is no clinical or scientific evidence to suggest that treatment with ACEi or ARBs should be discontinued because of the Covid-19 infection.

Important other expert opinions on this hypothesis can be found in the following link.  Some of these experts say that the jury is still out:

Expert reaction to questions about high blood pressure, diabetes, and ACE inhibitor drugs, and risk of COVID-19 infection

The following shows the tremendous complexity of this whole problem. Here is an interesting tweet from a doctor at Johns Hopkins. This doctor is working on novel therapeutics. He states in the tweet: “My recommended COVID19 treatment algorithm is starting patients who have more than mild symptoms or in high-risk category with: 1. Antiviral (chloroquine or hydroxychloroquine) 2. Losartan or other ARB (combat lung injury). Both proven w/ data, the latter acting on ACE2 pathway.'”  In the thread to his tweet he answers the concern about ARBs increasing ACE2 levels and claims the situation goes into reverse AFTER infection sets in as the viral infection causes ACE2 levels to drop.  Thus ARBs are helpful AFTER the fact: “it is beneficial for these drugs to increase ACE2. The lack of ACE2 leads to pulmonary edema.”  This looks like a case of initially damned if you do, but then damned AFTER if you don’t…

In conclusion, one should clearly not make any changes to your current medications while this debate plays out, but, in my personal opinion, we do not yet know what the final outcome will be, and the pandemic could be over before we do.  That is why I personally advise readers who take these medications to practice “social distancing” with particular diligence until the science is finally settled.

The following excellent JAMANetwork review article (which has section headings on the virus, epidemiology, clinical characteristics, case-fatality rates, screening and testing, clinical care and treatment, and prevention and infection control) just came to my attention via a tweet from Dr. Sanjay Gupta of CNN:

https://jamanetwork.com/journals/jama/fullarticle/2762510

Please scroll down to the Comments section below for further questions and information.

Nancy Bailey: There Can Be No “Science of Reading” When Libraries and Librarians Are Disappearing

An important article on Diane Ravitch’s blog:

Nancy Bailey: There Can Be No “Science of Reading” When Libraries and Librarians Are Disappearing

These are some of the Questions that I Want Answered about Coronavirus!

This blog normally focuses on education issues, but I am addressing the coronavirus pandemic here (and it is very likely a pandemic) because it is very probable that schools will be a primary mechanism of transmission if current quarantine efforts fail.  Kids just do not stay home from  school when ill, due in part to their desire not to fall behind, but also due to frantically busy parents shuffling them off so that the parents can go to work.

Sadly very often the media does not seem to have the expertise to ask the right questions.  I read a lot of news reports but have not seen answers to the following concerns.  Answers may exist, but, if so, they are not being distributed broadly.  CNN will have a special “town hall” the evening of March 5th on this topic, but my bet is that it will merely recycled the current oft-repeated news stories.  [Update – it turned out to be an EXCELLENT show.  Please see the Comments section following this article for details.  Regarding school closures, one participant noted that in poor areas closing the schools may also mean that some kids will miss their only good meal of the day.]

  1. We hear that 80% of the cases are “mild” and yet young healthy people, like the ophthalmologist who was one of the first who reported the disease in China, became extremely ill and died.  This can be due to many factors.  Initially it was thought that the doctor was exposed to a patient from the Wuhan marketplace with a very high “viral load”.  However, there may be multiple strains of the virus circulating of varying mortality (I have been wondering about this for some time and CNBC just reported this news finally this AM).  The CNBC report stated that the initial virus may have caused more severe illness than the more recent mutation, but data is still preliminary. Evolutionary pressure favors viruses that do NOT kill their hosts because a virus needs its host to replicate.  There are also possible genetic variations in cell surface proteins that viruses may target, possibly making it cause more serious disease in some people than others.  We need people in the government and media with the appropriate scientific background to look into these questions and get better information out to the public.  No discussion that I have heard to date has addressed any of the above, but instead focuses merely on obvious items like hand washing and the pros and cons of wearing masks.
  2. Reports abound of the virus mysteriously circulating in communities “undetected” and then cases suddenly appearing due to “community transmission.”  Clearly one wonders about the availability AND reliability of coronavirus test kits.  I read earlier that the initial kits distributed by the CDC were flawed and had to be replaced.  We have to resign ourselves to the fact that, in the middle of regular flu season, many cases of illness are NOT going to be tested.  Secondly, even if they are tested, what is the rate of false positives and false negatives for these tests?  The media immediately seems to report positives tests as gospel truth.  Without knowing the validity of the tests we do not know how much to trust this data. (False negative rate reported on 3/4/2020 to be <4% – see Comment section below). (3/5/20 – SF Chronicle article link in Comments below shows some patients getting variable results during repeated tests.)
  3. We heard the other day that there are over 8000 people in California alone under self-quarantine and I have seen reports that the number is over 9000.  Initial quarantines occurred at Travis Air Force base and other bases in southern California.  I have seen almost no follow-up reporting about the outcomes of any of these quarantines.  I would imagine by now that many of the people have been released, but the media seems less excited about reporting such news.  I would hope that our state public health agency is monitoring this list and is providing updates somewhere as to whether the quarantine case load is increasing or decreasing.  The media needs to focus on reporting this information as well as the more sensational stories of people testing positive for the virus.

I will update this article with other concerns as more information becomes available; so please check back again and look at the Comments section below.

SMUHSD Class Sign-up Time – Please Read This First!

Each year I receive calls for help part way into the new school year from parents whose children signed up for too many AP classes. I usually can not help these students because my schedule is already full, so I wrote the following article to try to stave off these problems to the extent possible. This article is an update for 2020 of my experience with AP Science and Math classes. Most of my students attend Aragon, but the cautionary notes in this article should also be considered by those attending other SMUHSD schools.

Continue reading “SMUHSD Class Sign-up Time – Please Read This First!”

SF Chronicle: Chaos at SF’s Aptos Middle School

School disciplinary problems reflect bigger issues in our society. I believe there is a connection between them and the increase in car burglaries and other thefts/break-ins in our community.

Problems locally may also be impacting the regular stream classes, especially in math.

The San Francisco Chronicle has a podcast entitled “Fifth & Mission.”  On Feb. 15th, 2020 the topic was “Chaos upends San Francisco’s Aptos Middle School.”  The podcast is a discussion of Heather Knight’s column of the same date entitled “‘Lord of the Flies’: Fights, bullying, chaos upend San Francisco middle school.

Aptos Middle School is near the well-to-do St. Francis Wood and Monterey Heights neighborhoods several blocks east of Stonetown Galleria, but has students bussed in from other parts of the City including the poorer Bayview and Portrero Hill neighborhoods.  Somewhere between only 5-20 students between the ages of 11-14 years old at the school

managed to wrest control of the school from the adults.

And everybody agrees these kids, just 11 to 14 years old, need far more support to cope with the horrifying trauma they’ve experienced in their short lives and get them engaged in school. Where families and teachers disagree with administrators, however, is whether the school district — which is big on talk about social justice — is actually providing that support.

The district says it is. But the mayhem — physical fights, bullying, chaotic hallways and vile language — shows that’s clearly not the case.

In fact, for the 1,000 students at Aptos, there’s just one social worker. And the only real concession the district has made after complaints about safety has been allowing Principal Nicole Trickett to use money tagged for new technology to hire a temporary security guard for more protection in the hallways.

Why should this concern us here in the suburbs??

In the course of my tutoring work, I talk to students every day about their classes.  While we may not have problems locally that are quite this severe, this is not isolated to Aptos Middle School.  I taught for a year at one of the better high schools in San Francisco where a female teacher was beaten up by two female students who were subsequently suspended.  I constantly saw kids roaming the halls when they should be in class and at times deciding to barge in to other classrooms to talk to their friends in the middle of lessons.

The disrespect shown to teachers and the constant barrage of foul language in the halls between periods was shocking enough to me at the time, and I would not be surprised if it has become worse since then.

I generally work with more serious SMUHSD students in precalculus, calculus, physics and chemistry, but have some students in the regular math stream.  I often hear that about half the regular math classes are filled with students who come in to high school with very weak math backgrounds, have basically given up on the subject, and cause disruptions in class.  This clearly impacts the learning of the better students in the class.  I have no quantitative data on how frequently this happens, but I suggest that parents reading this article talk to their own kids and try to get a sense of the occurrences from them.

In the past I have written many times with a degree of disapproval about the frantic rush to accelerate kids in math, and said that the regular stream should be considered.  However, I have also argued for an honors stream that presented the material at a level in between the regular and AP classes.  There seems to me to be a significant number of students who would benefit from this intermediate stream which would save them the stress and expense of the AP exams.  Possibly due to lack of resources this has never gone anywhere despite a similar attempt by Aragon parents several years ago to request an honors stream from the administration.

When I first started tutoring eight years ago, I had several regular stream students and was fairly satisfied with the regular math classes at that time.  However, as my reputation grew, I increasingly focussed on the higher level math classes.  Since I have worked with some families for as long as 6-7 years, I have accepted some siblings in regular stream math classes in the last few years and am now concerned about the pace of the regular curriculum.  These students are competent in math but are bored in the regular math classes.  Textbooks have been abandoned in favor of worksheets, and the level of difficulty seems to have decreased.  One Algebra 1 class this school year spent the first 10 to 11 weeks on simplifying algebraic expressions and the slope-intercept, point-slope and standard formats for the equation of a line.  Most work was completed in class and a weekly homework worksheet took the student only about 20 minutes to finish.

Possibly because teachers have to deal with such a wide variety of math skills (and this problem may have been exacerbated by aborted curriculum experiments such as Everyday Math in the local K-8 district), this slowdown may have been necessary.

However, combining a slower curriculum with kids that are bored with or given up on math is a recipe for problems.

Public school teachers are in a tough position with disruptive kids.  Serra High School, a local Catholic school, had a staffed after-school detention center for discipline problems which gave Serra teachers an acceptable disciplinary option.

Many public high schools require the teacher who assigns detention to stay after school to monitor the student themselves!  This clearly does not encourage teachers to use detention as a disciplinary tool.  Instead, for example, when I taught in SFUSD, the helpful classroom management advice that I was given by a vice principal was simply, “Don’t let them see you smile until after Christmas!”, i.e., the teacher is expected to control the classroom by giving stern looks and emulating a prison guard persona!  Whatever happened to parental responsibility for teaching their kids proper behavior?  When I tried to call home to talk to parents, I frequently found that the parents were not available because they were working two minimum wage jobs to make ends meet and older children were taking care of younger kids!

Stern looks will clearly not work with disruptive kids from traumatized family backgrounds, some of whom have no hesitation to yell, “FU, I don’t have to listen to you!” and storm out of a classroom.  A relative of mine worked as a school security officer in southern California and has told me stories of veteran teachers coming to him in tears telling him that they can no longer control these kids.

Various ACLU lawsuits have enhanced student “rights” over the years, to the detriment of teachers in my opinion, and I have also heard of cases where teachers have been threatened with lawsuits by parents to halt disciplinary measures against their children.

Public schools also have to accept and teach all students, and, instead of the “old school” method of streaming kids into advanced, regular, and remedial classes, the tendency now is to “mainstream” the slower students and have them work in groups with some of the better students, in the hope that they will learn from their peers as well as from teachers / “authority figures.”  While this may work to some extent, it has also led to interesting incidents like a student being criticized by their group for being out sick, thereby resulting in a lower grade for others in the group!!

Our society can no longer afford to ignore the trauma in the poorer segments of society if for no other reason than the cynical one that it negatively impacts the rest of us.  Drug addiction, homelessness, joblessness, single-mother families –  the list goes on.

If children emerge from school without a decent education, their odds of becoming productive members of society are clearly lowered significantly.  Even worse, if they leave school with the idea that they can engage in antisocial behavior with impunity, do not be surprised if you can’t leave your cars at night with anything visible inside of them or that people brazenly snatch iPhones and iPads in broad daylight from Apple Stores.

San Francisco is not that far from San Mateo…

For some thoughtful perspectives and possible solutions for these problems I recommend the following:

Hope and despair in the American city – Why there are no bad schools in Raleigh by Gerald Grant

and chapter 6 entitled “The Only Valid Passport from Poverty” in the book

The Teacher Wars – A History of America’s Most Embattled Profession by Dana Goldstein.

I only hope that we have not let this situation fester until it is too late to act.

 

Prepared?

A serendipitous chain of events – frustration after reviewing for an AP physics final leads me to begin reading a new book by the co-founder of Summit charter schools. Is there a path out of the current education morass?!??

Friday the 13th, December 2019 – Fall semester is coming rapidly to a close and everyone, myself included, is busily reviewing/helping review for final exams.

Last night I was working with one of my favorite students who is taking AP physics.  I only meet with this student once a week for a session of up to two hours, but, as we started going over the review packet for the final, I was chagrined, once again, to see that most of the material covered early in the semester had been almost completely forgotten.  I’ve been tutoring AP physics for the last 8 years now, and this year’s review packet also contained some ambiguous questions which did not help matters.

I encounter this situation every year, but this student in particular is excellent, so it bothered me even more than usual this time.

Readers of this blog know quite well that I have not been a fan of the AP system.  AP physics in particular tends to cover too much material far too quickly.  Nationally in 2019 the AP Physics 1 exam had the lowest average score of any AP test (2.51 on a scale of 5) with a pass rate of only 45.4%.  This is despite the redesign of the exam in 2015 when the College Board reacted to poor scores by cutting back the material covered PLUS the even more amazing fact that students need only around 41% correct answers to get a passing grade of 3!

In the rush to cover the topics even on the newer pared-down exam, it is crystal clear to me that insufficient practice problems are given to students before the class needs to move on to the next topic in the frantic rush to “cover the material.”

I believe that the sacred trust of high school teachers is to inspire interest and enthusiasm in the subject taught, not overwhelm students with so many details that they end up feeling stupid and frustrated.

Physics is a hard topic to begin with, but should be the most fun and enlightening class a student takes in high school.  Very few students are fortunate enough to have this experience in high school (neither did I; college physics saved me fortunately).

When a teacher is forced to teach to the requirements of the AP exam (the main purpose of which is to spread out the curve to help college admissions offices sort through applicants), the pace of the curriculum is not conducive to generating a love for the subject; in fact, it sadly does the exact opposite!!

I have been working with the student above for several years and was really looking forward to studying physics with them this year (unfortunately due to my public writings I have to use gender neutral references).  It was crushing to see that “the system” was crashing down on things yet again.

Starting today off in a foul mood because of the above, I decided to go to lunch at Filoli, one of my favorite places around the holidays.  After eating, I walked around the now dormant rose garden and took a seat under a large persimmon tree to read.

I was scrolling through my WordPress blog list, perusing a few articles from Diane Ravitch’s education blog, when I ran across a post from Bill Gates, reviewing a new book by the co-founder and CEO of Summit charter schools, Diane Tavenner.  The title of the book is “Prepared: What Kids Need for a Fulfilled Life.”  Summit schools started out right here in the Bay Area originally sharing space with Sequoia High School in Redwood City.

Anyone who knows the history of Dr. Ravitch and Mr. Gates might be surprised that I look at both blogs.  Dr. Ravitch leads public school advocates and is vehemently opposed to privatization/charter schools.  Mr. Gates has been one of the largest funders and supporters of the public school “reform” movement.  The vitriol flung back and forth between these two camps can be overwhelming at times.

As to reading both blogs, I admit that I am a dinosaur – one of the few remaining Americans who believes in investigating the many sides of the story instead of just tuning to MSNBC or Fox News all day long to reinforce my prejudices.

I downloaded a free Kindle sample of Ms. Tavenner’s book and read it engrossed while sitting in Filoli’s rose garden.  The story in the book’s Prologue about a student named Isabella who succeeded at Summit despite amazing odds against her was riveting.  I quickly finished the Prologue, chapter 1, and the first part of chapter 2 when I reached the end of my freebie.  I then paid for the rest of the book which I hope to finish over the winter break, and will report back more later.

Ms. Tavenner focuses a lot in the free Kindle excerpt on disadvantaged students struggling to make it in our society (including herself at a younger age), and near the end of the first chapter mentions their “Summit Learning” software program “in which other schools could have access to the resources, curriculum, and tools we use, for free.”  She mentions Summit’s method of personalizing education for each student using technology, and how every student is paired with teacher and student mentors to help them succeed.  In contrast to the rushed AP system, learning is self-paced, but “100 percent of of our graduates are eligible for a four-year college, and 98% are accepted.  Summit grads finish college at double the national average, and the rate is much higher for minority students.”

Sounds very good, and I look forward to reading the rest!

However, I should also note that Summit Learning and the personalized learning approach in general has generated its fair share of controversy as noted in these articles:

So is Ms. Tavenner’s new book going to turn out to be a marketing tool for Summit Learning?  I don’t know yet.

I have used the ALEKS software with some of my math students for supplemental self-paced instruction.  My personal experience casts doubt about putting a student alone in front of a computer.  Unless an adult is sitting with the student while they work through the program, it tends not to get used, and the computers are often used instead as a tool to access other distractions.  HOWEVER, with close adult supervision, I believe it can be a valuable additional tool in a teacher’s quiver of arrows.  The fourth article “2011 Video…” in the list above makes one wonder, however, if technology will in fact be used that way.

Despite these reservations, I look forward to reading the rest of “Prepared: What Kids Need for a Fulfilled Life.”

Sadly, what I currently see in our public schools does not bring me joy either…

On that cheerful note – Happy Holidays!!